The U.S. AI startup ecosystem is maintaining its momentum in 2025, building on a blockbuster 2024. Last year, 49 startups raised $100M+ rounds, with seven companies securing billion-dollar investments. The trend is continuing in 2025, with several mega-rounds already closed in the first half of the year.
Below is a list of 24 U.S.-based AI startups that have raised $100 million or more so far this year:
June
- Glean – $150M Series F led by Wellington Management; Valued at $7.25B
- Anysphere (Cursor) – $900M Series C led by Thrive Capital; Valued at nearly $10B
→ Learn more about Cursor: Anysphere’s AI Dev Tool Cursor
May
- Snorkel AI – $100M Series D led by Addition; Valued at $1.3B
→ Learn more about data-centric AI: Snorkel AI’s Labeling Platform - LMArena – $100M seed round co-led by Andreessen Horowitz; Valued at $600M
- TensorWave – $100M Series A co-led by Magnetar Capital and AMD Ventures
April
- SandboxAQ – $450M Series E with Nvidia and Google; Valued at $5.7B
→ Quantum meets AI: Explore SandboxAQ - Runway – $308M Series D led by General Atlantic; Valued at $3B
→ Creative AI in action: Visit Runway’s Platform
March
- OpenAI – $40B round led by SoftBank; Valued at $300B
- Nexthop AI – $110M Series A led by Lightspeed
- Insilico Medicine – $110M Series E; Valued at $1B
- Celestial AI – $250M Series C; Valued at $2.5B
- Lila Sciences – $200M seed round for science superintelligence
- Reflection.AI – $130M Series A; Valued at $580M
- Turing – $111M Series E; Valued at $2.2B
- Shield AI – $240M Series F; Valued at $5.3B
- Anthropic – $3.5B Series E; Valued at $61.5B
February
- Together AI – $305M Series B; Valued at $3.3B
- Lambda – $480M Series D; Valued at ~$2.5B
- Abridge – $250M Series D; Valued at $2.75B
- Eudia – $105M Series A
- EnCharge AI – $100M Series B
- Harvey – $300M Series D; Valued at $3B
January
- ElevenLabs – $180M Series C; Valued at $3B+
- Hippocratic AI – $141M Series B; Valued at $1.6B+
This list will be updated as more funding rounds are announced. The AI funding surge shows no signs of slowing, as startups continue to raise capital to fuel infrastructure, healthcare, legal tech, and generative AI tools across industries.
Also Read : Multiplier Raises $27.5M to Build an AI-Powered Accounting Roll-Up Empire
